00:00-00:51
[The Zepbound logo animate s on screen, followed by the Indication and Limitations of Use. Upbeat music plays.]
CAPTION: HOW TO USE once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
Indication and Limitations of Use
NARRATOR: Indication and Limitations of Use. Zepbound is an injectable prescription medicine that may help adults with obesity, or with excess weight (overweight) who also have weight-related medical problems, lose weight and keep it off. Zepbound should be used with a reduced-calorie diet and increased physical activity.
Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective when taken with other prescription,over-the-counter, or herbal weight loss products. It is not known if Zepbound can be used in people who have had pancreatitis. It is not known if Zepbound is safe and effective for use in children under 18 years of age.
00:51-01:27
[Select Safety Information animates on screen.]
CAPTION: HOW TO USE once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
Select Safety Information
NARRATOR: Select Safety Information. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats, Zepbound and medicines that work like Zepbound caused thyroid tumors, including thyroid cancer. It is not known if Zepbound will cause thyroid tumors, or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people. Do not take Zepbound if you or any of your family have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
01:27-01:32
CAPTION: HOW TO USE once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
NARRATOR: See Indication and Safety Summary with Warnings at the end of this video.
01:32-01:38
CAPTION: HOW TO USE once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
NARRATOR: In this video you will learn how to inject Zepbound using the single-dose vial and a needle and a syringe.
01:38-1:54
[An illustration of a refrigerator animates on screen. The Zepbound logo appears and remains on screen in the lower right-hand corner.]
CAPTION: Getting started with your Zepbound® (tirzepatide) injection
Read the Instructions for Use before you start taking Zepbound and each time you get a new vial.
Do not share your needles or syringes with other people. You may give other people a serious infection or get a serious infection from them.
NARRATOR: Be sure to read the Instructions for Use before you start taking Zepbound and each time you get a new vial.There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment.
01:54-02:03
[A carton of Zepbound animates on screen.]
CAPTION: Getting started with your Zepbound® (tirzepatide) injection
Read the Instructions for Use before you start taking Zepbound and each time you get a new vial.
Do not share your needles or syringes with other people. You may give other people a serious infection or get a serious infection from them.
NARRATOR: Do not share your needles or syringes with other people. You may give other people a serious infection or get a serious infection from them.
02:03-02:19
[A carton of Zepbound and vial animate on screen.]
CAPTION: Getting started with your Zepbound® (tirzepatide) injection
Read the Instructions for Use before you start taking Zepbound and each time you get a new vial.
Do not share your needles or syringes with other people. You may give other people a serious infection or get a serious infection from them.
NARRATOR: The Zepbound single-dose vial is a subcutaneous injection, which means it is injected under the skin. Ready to learn how to use the Zepbound single-dose vial? Let’s begin with preparing for your once-weekly injection.
02:19-02:25
[An illustration of the inside of an open refrigerator door animates on screen, highlighting a carton of Zepbound on one of the shelves.]
CAPTION: Preparing for your Zepbound® injection
• Remove the vial from the refrigerator
NARRATOR: Remove the vial from the refrigerator.Remove the single-dose vial from the carton.
02:25-02:33
[The refrigerator illustration fades away as the animation zooms in on a Zepbound vial.]
CAPTION: The Zepbound® vial
• Check the medicine and dose
• Check that it has not expired
NARRATOR: Check the single-dose vial label to make sure you have the right medicine and dose and that it has not expired.
02:33-02:43
[A blue line highlights the medicine at the bottom of the Zepbound vial.]
CAPTION: The Zepbound® vial
• The medicine is colorless to slightly yellow
• Make sure the medicine is not frozen, not cloudy, and does not have particles in it
NARRATOR: Make sure the medicine is colorless to slightly yellow. Make sure the medicine is not frozen, not cloudy, and does not have particles in it.
02:43-03:01
[In addition to the Zepbound vial, a syringe and needle, an alcohol swab, gauze, and a sharps container animate on screen.]
CAPTION: Preparing for your Zepbound® injection
Gather supplies:
• 1 single-dose Zepbound vial
• 1 syringe and 1 needle, supplied separately
• 1 alcohol swab
• Gauze
• 1 sharps container for throwing away used needles and syringes
The needle and syringe are not included. The needle and syringe recommended by your healthcare
provider may look different than the needle and syringe in this Instructions for Use video.
NARRATOR: Gather supplies needed to give your injection. You will need: one single-dose Zepbound vial, one syringe and one needle(supplied separately),one alcohol swab, gauze, and one sharps container for throwing away used needles and syringes.
03:01-03:18
[Text animates on screen.]
CAPTION: Preparing for your Zepbound® injection
Always use a new syringe and needle for each injection to prevent infections and blocked needles. Do not reuse or share your syringes or needles with other people. You may give other people a serious infection or get a serious infection from them.
NARRATOR: Always use a new syringe and needle for each injection to prevent infections and blocked needles. Do not reuse or share your syringes or needles with other people. You may give other people a serious infection or get a serious infection from them.
We will now review the steps to inject your dose of Zepbound.
03:18-03:23
[A pair of hands move back and forth with bubbles animating in the background.]
CAPTION: Preparing for your Zepbound® injection
• Wash your hands
NARRATOR: Get ready for your injection by washing your hands with soap and water.
03:23-03:32
[A diagram of a person animates on screen, purple ovals highlighting the stomach area and thighs.]
CAPTION: Choose your injection site
• You or someone else can inject Zepbound under the skin of your stomach area (abdomen) or thighs
NARRATOR: Choose your injection site. You or someone else can inject Zepbound under the skin of your stomach area or abdomen or thighs.
03:32-03:49
[Purple ovals highlight the upper arms on the diagram of the person.]
CAPTION: Choose your injection site
• Someone else can give you the injection in the back of your upper arm
• Change (rotate) your injection site with each weekly injection. You may use the same area of your body but be sure to choose a different injection site in that area. Do not use the same site for each injection
NARRATOR: You can have another person give you the injection in the back of your upper arm. Change or rotate your injection site with each weekly injection. You may use the same area of your body, but be sure to choose a different injection site in that area. Do not use the same site for each injection.
03:49-03:59
[A person’s hands holding a Zepbound vial animate on screen. The hands remove the cap and wipe the rubber stopper with an alcohol swab.]
CAPTION: Prepare the vial
• Pull off the plastic protective cap
• Do not remove the rubber stopper
• Wipe the rubber stopper with the alcohol swab
NARRATOR: Begin by pulling off the plastic protective cap, but do not remove the rubber stopper. Wipe the rubber stopper with an alcohol swab.
03:59-04:03
[The hands remove the outer wrapping from a syringe and needle.]
CAPTION: Attach the syringe and needle
• Remove the outer wrapping from the syringe and needle
NARRATOR: Next, you will need to remove the outer wrapping from the syringe and needle.
04:03 -04:14
[The needle twists onto the syringe until tight and firmly attached.]
CAPTION: Attach the syringe and needle
• Remove the outer wrapping from the syringe and needle
• Attach the needle to the top of the syringe
NARRATOR: Place the needle on top of the syringe and turn until it is tight and firmly attached. You can omit this step if the needle and syringe are already attached.
04:14 -04:17
[The hands pull the needle shield off the syringe.]
CAPTION: Prepare the syringe and needle
• Remove the needle shield by pulling straight off
NARRATOR: Now, remove the needle shield by pulling it straight off.
04:17-04:31
[One hand holds the syringe pointing up while the other hand pulls down on the plunger. A graphic animates on screen, show ing a close-up of the syringe and highlighting the plunger tip reaching the 0.5 - mL line.]
CAPTION: Prepare the syringe and needle
• Hold the syringe pointed up
• Pull down until the plunger tip reaches 0.5 mL of air
NARRATOR: Hold the syringe in one hand with the needle pointing up. With the other hand, pull down on the plunger until the plunger tip reaches the line on the syringe indicating that 0.5 milliliters of air has been drawn into the syringe.
04:31 -04:35
[One hand holds the vial while the other hand pushes the needle through the vial’s rubber stopper.]
CAPTION: Push the needle in
• Push the needle through the rubber stopper of the vial
NARRATOR: Then, push the needle through the rubber stopper of the vial.
04:35-04:41
[One hand holds the vial while the other hand pushes the plunger all the way into the vial.]
CAPTION: Push the plunger in
• Push the needle through the rubber stopper of the vial
• Push the plunger all the way in
• This puts air into the vial
NARRATOR: Push the plunger all the way in. This puts air into the vial and makes it easier to pull the solution from the vial.
04:41-04:55
[One hand holds the vial and syringe upside down. The other hand pulls the plunger down. A graphic animates on screen, showing a close-up of the syringe and highlighting the plunger tip extending beyond the 0.5 - mL line.]
CAPTION: Fill the syringe
• Turn the vial and syringe upside down
• Pull the plunger down until the plunger tip is past 0.5 mL
Ensure the tip of the needle is in the liquid in the vial.
NARRATOR: Next, you will need to turn the vial and syringe upside down. Make sure that the tip of the needle is in the liquid and slowly pull the plunger down until the plunger tip is past the 0.5-milliliter line.
04:55 - 05:00
[One hand holds the vial and syringe upside down. The other hand flicks the syringe to remove air bubbles.]
CAPTION: Fill the syringe
• Tap the syringe if there are any air bubbles
NARRATOR: If there are air bubbles, tap the syringe gently a few times to let any air bubbles rise to the top.
05:00-05:07
[One hand holds the vial and syringe upside down. The other hand pushes the plunger up with its thumb. A graphic animates on screen, showing a close-up of the syringe and highlighting the plunger tip extending to the 0.5 - mL line.]
CAPTION: Finish syringe preparation
• Push the plunger up until the plunger tip reaches 0.5 mL
NARRATOR: Then, slowly push the plunger up until the plunger tip reaches the 0.5-milliliter line.
05:07-05:12
[One hand holds the vial. The other hand pulls the syringe out of the vial.]
CAPTION: Finish syringe preparation
• Push the plunger up until the plunger tip reaches 0.5 mL
• Pull the syringe out
NARRATOR: Pull the syringe out of the rubber stopper of the vial.
05:12-05:24
[The Zepbound logo disappears from the lower right-hand corner. Holding their shirt up to reveal their stomach area, a person inserts the needle into their skin and pushes down on the plunger of the syringe—holding it in place for five seconds.]
CAPTION: Injecting the medicine
• Insert the needle into your skin
• Push down on the plunger
• The needle should stay in for at least 5 seconds
NARRATOR: Now, insert the needle into your skin and push down on the plunger to inject your dose. The needle should stay in your skin for at least five seconds to make sure you have injected all of your dose.
05:24-05:36
[The person pulls the needle out of their skin. A sharps container animates on screen. The needle and syringe drop safely into the container. The Zepbound logo re-appears on screen in the lower right-hand corner.]
CAPTION: Injecting the medicine
• Insert the needle into your skin
• Push down on the plunger
• The needle should stay in for at least 5 seconds
• Pull out the needle
• Do not recap the needle. Recapping the needle can lead to a needle stick injury
• Place the used needle and syringe directly into your FDA-cleared sharps container
NARRATOR: Pull the needle out of your skin. Do not recap the needle. Recapping the needle can lead to a needle stick injury. Place the needle and syringe directly into your sharps container.
05:36-05:45
[Holding their shirt up to reveal their stomach area, the person presses their injection site with an alcohol swab. The Zepbound logo disappear s from the lower right-hand corner.]
CAPTION: Injecting the medicine
• If you see blood, press the injection site with a piece of gauze or alcohol swab
• Do not rub the area
NARRATOR: If you see blood after you take the needle out of your skin, press the injection site with a piece of gauze or an alcohol swab. Do not rub the area.
05:45-05:50
[A sharps container animates on screen. The Zepbound logo re-appears on screen in the lower right-hand corner.]
CAPTION: Disposing of used needles and syringes
• Do not throw away needles and syringes in your household trash
NARRATOR: Do not throw away needles and syringes in your household trash.
05:50-06:23
[The sharps container remains on screen. A green hazardous waste label animates on and off screen.]
CAPTION: Disposing of used needles and syringes
• If you do not have a sharps disposal container, you may use a household container that is:
• Made of a heavy-duty plastic
• Fit with a puncture-resistant lid that can be closed tightly without sharps being able to come out
• Upright and stable during use
• Leak-resistant
• Properly labeled to warn of hazardous waste inside the container
• Do not recycle your used sharps disposal container
• Keep Zepbound vials, syringes, needles, and all medicines out of the reach of children
NARRATOR: If you do not have an FDA-cleared sharps disposal container, you may use a household container that is made of a heavy-duty plastic, fit with a puncture-resistant lid that can be closed tightly without sharps being able to come out, upright and stable during use, leak-resistant, and properly labeled to warn of hazardous waste inside the container.
Do not recycle your used sharps disposal container. Follow your community guidelines for the right way to dispose of your sharps disposal container.
Keep Zepbound vials, syringes, needles, and all medicines out of the reach of children.
06:23-06:38
[Text animates on screen.]
CAPTION: If you have any questions about injecting Zepbound® (tirzepatide) or problems with your
Zepbound vial, contact your healthcare provider or Lilly at 1-800-LillyRx (1-800-545-5979).
For more information about Zepbound, visit our website at zepbound.lilly.com
Zepbound® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates. Zepbound is available by prescription only. PP-ZP-US-0952 08/2024 ©Lilly USA, LLC 2024. All rights reserved.
NARRATOR: If you have any questions or concerns about administering Zepbound, please contact your healthcare provider or Lilly at 1-800-LillyRx (1-800-545-5979).
06:38-14:42
[Text animates on screen and begins scrolling. The Zepbound logo animate s on the upper right-hand corner of the screen.]
CAPTION: INDICATION AND SAFETY SUMMARY WITH WARNINGS
once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
NARRATOR: INDICATION AND SAFETY SUMMARY WITH WARNINGS. Zepbound is an injectable prescription medicine that may help adults with obesity, or with excess weight (overweight) who also have weight-related medical problems, lose weight and keep it off. It should be used with a reduced-calorie diet and increased physical activity.
Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective when taken with other prescription, over-the-counter, or herbal weight loss products. It is not known if Zepbound can be used in people who have had pancreatitis. It is not known if Zepbound is safe and effective for use in children under 18 years of age.
Warnings. Zepbound may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath. If you have any of these symptoms, tell your healthcare provider.
Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC). Do not use Zepbound if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Do not use Zepbound if you have had a serious allergic reaction to tirzepatide or any of the ingredients in Zepbound.
Zepbound may cause serious side effects, including:
Severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Zepbound. Tell your healthcare provider if you have stomach problems that are severe or will not go away.
Kidney problems (kidney failure). Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration.
Gallbladder problems. Gallbladder problems have happened in some people who use Zepbound. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include pain in your upper stomach (abdomen), fever, yellowing of skin or eyes (jaundice), or clay-colored stools.
Inflammation of the pancreas (pancreatitis). Stop using Zepbound and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back.
Serious allergic reactions. Stop using Zepbound and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, or very rapid heartbeat.
Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Zepbound with medicines that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness or feeling jittery.
Changes in vision in patients with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with Zepbound.
Depression or thoughts of suicide. You should pay attention to changes in your mood,behaviors, feelings or thoughts. Call your healthcare provider right away if you have any mental changes that are new, worse, or worry you.
Common side effects. The most common side effects of Zepbound include nausea, diarrhea, vomiting, constipation, stomach (abdominal) pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss, and heartburn. These are not all the possible side effects of Zepbound. Talk to your healthcare provider about any side effect that bothers you or doesn’t go away.
Tell your healthcare provider if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.
Before using Zepbound. Your healthcare provider should show you how to use Zepbound before you use it for the first time. Tell your healthcare provider if you are taking medicines to treat diabetes including insulin or sulfonylureas which could increase your risk of low blood sugar. Talk to your healthcare provider about low blood sugar levels and how to manage them. If you take birth control pills by mouth, talk to your healthcare provider before you use Zepbound. Birth control pills may not work as well while using Zepbound. Your healthcare provider may recommend another type of birth control for 4 weeks after you start Zepbound and for 4 weeks after each increase in your dose of Zepbound.
Review these questions with your healthcare provider. Do you have other medical conditions, including problems with your pancreas or kidneys, or severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems digesting food? Do you take diabetes medicines, such as insulin or sulfonylureas? Do you have a history of diabetic retinopathy? Do you take any other prescription medicines or over-the-counter drugs,vitamins, or herbal supplements? Are you pregnant, plan to become pregnant, breastfeeding, or plan to breastfeed? Zepbound may harm your unborn baby. Tell your healthcare provider if you become pregnant while using Zepbound. It is not known if Zepbound passes into your breast milk. You should talk with your healthcare provider about the best way to feed your baby while using Zepbound.
Pregnancy Exposure Registry. There will be a pregnancy exposure registry for women who have taken Zepbound during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry, or you may contact Lilly at 1-800-LillyRx (1-800-545-5979).
How to take. Read the Instructions for Use that come with Zepbound. Use Zepbound exactly as your healthcare provider says. Zepbound is injected under the skin (subcutaneously) of your stomach (abdomen), thigh, or upper arm. Use Zepbound 1 time each week, at any time of the day. Change (rotate) your injection site with each weekly injection. Do not use the same site for each injection. If you take too much Zepbound, call your healthcare provider, seek medical advice promptly, or contact a Poison Center expert right away at 1-800-222-1222.
Learn more. Zepbound is a prescription medicine. For more information, call 1-800-LillyRx (1-800-545-5979) or go to www.zepbound.lilly.com.
This summary provides basic information about Zepbound but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Zepbound and how to take it. Your healthcare provider is the best person to help you decide if Zepbound is right for you.
ZP CON CBS 08NOV2023
Zepbound®and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.
14:42-14:45
[The Zepbound logo animates on screen.]
CAPTION: once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
visit zepbound.lilly.com
A Lilly Medicine
14:45-14:51
[The Lilly logo animates on screen.]
CAPTION: Lilly
A MEDICINE COMPANY
©Lilly USA, LLC 2024. All rights reserved.
Zepbound® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.
